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Gene name:
Angpt1(Agpt);
Protein name:
Angiopoietin-1(ANG-1);
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
N/A
Function:
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.
Subcellular Location:
Secreted
Protein Attributes:
Sequence length:
498
Sequence:
50:
MTVFLSFAFF | AAILTHIGCS | NQRRNPENGG | RRYNRIQHGQ | CAYTFILPEH |
100:
DGNCRESATE | QYNTNALQRD | APHVEPDFSS | QKLQHLEHVM | ENYTQWLQKL |
150:
ENYIVENMKS | EMAQIQQNAV | QNHTATMLEI | GTSLLSQTAE | QTRKLTDVET |
200:
QVLNQTSRLE | IQLLENSLST | YKLEKQLLQQ | TNEILKIHEK | NSLLEHKILE |
250:
MEGKHKEELD | TLKEEKENLQ | GLVSRQTFII | QELEKQLSRA | TNNNSILQKQ |
300:
QLELMDTVHN | LISLCTKEGV | LLKGGKREEE | KPFRDCADVY | QAGFNKSGIY |
350:
TIYFNNMPEP | KKVFCNMDVN | GGGWTVIQHR | EDGSLDFQRG | WKEYKMGFGN |
400:
PSGEYWLGNE | FIFAITSQRQ | YMLRIELMDW | EGNRAYSQYD | RFHIGNEKQN |
450:
YRLYLKGHTG | TAGKQSSLIL
